Olivera Stojadinovic, MD PhD

Publications – Peer Reviewed Journal Articles/Abstracts/Book Chapters

Psoriasis

• Egger A, Maderal A, Lev-Tov H, Stojadinovic O. A Case Report of a Patient with Turner Syndrome, Multiple Comorbidities, and Pustular Psoriasis: Correlation or Coincidence? Case Rep Dermatol Med. 2020 Jan 8;2020:5750309. doi: 10.1155/2020/5750309. eCollection 2020

MRSA / Staph Infection

• Strbo N, Pastar I, Romero L, Chen V, Vujanac M, Sawaya AP, Jozic I, Ferreira AF, Wong LL, Head C, Stojadinovic O, Garcia D, O’Neill K, Drakulich S, Taller S, Kirsner RS, Tomic-Canic M. Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection. Exp Dermatol. 2019 Mar;28(3):225-232
• Ramirez HA, Pastar I, Jozic I, Stojadinovic O, Stone RC, Ojeh N, Gil J, Davis SC, Kirsner RS, Tomic Canic M. Staphylococcus aureus Triggers Induction of miR-15B-5P to Diminish DNA Repair and Deregulate Inflammatory Response in Diabetic Foot Ulcers. J Invest Dermatol. 2018 May;138(5):1187 1196
• McCormack RM, de Armas LR, Shiratsuchi M, Fiorentino DG, Olsson ML, Lichtenheld MG, Morales A, Lyapichev K, Gonzalez LE, Strbo N, Sukumar N, Stojadinovic O, Plano GV, Munson GP, Tomic-Canic M, Kirsner RS, Russell DG, Podack ER.Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria. (2015) Elife. 24; 4. doi: 10.7554/eLife.06508.
• Pastar I., Nusbaum A.G., Gil J., Valdes J., Stojadinovic O. , Plano L., Cancio L., Tomic-Canic M., Davis S. C.. Interactions of Methicilin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection, Plos One. (2013); 8(2):

Hair loss / Alopecia

• Nemcevic A, Stojadinovic O, Miteva M: Folliculitis decalvans and lichen planopilaris phenotypic spectrum – a series of 7 new cases with focus on histopathology. Am J Dermatopathol. 2020 Mar;42(3):173-177.

PRP

• Stojadinovic O, Morrison B, Tosti A. Adverse effects of Platelet Rich Plasma and Microneedeling. J Am Acad Dermatol. 2019 Aug 10. pii: S0190-9622(19)32554-X. doi: 10.1016/j.jaad.2019.07.109.

Skin Cancer

• Stojadinovic O, Ramirez H, Pastar I, Gordon KA, Stone R, Choudhary S, Badiavas E, Nouri K, Tomic Canic M. MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas. Arch Dermatol Res. 2016 Dec 24. doi: 10.1007/s00403-016-1705-0.
• Yin N., Miteva M., Covington D.S., Romanelli P. Stojadinovic O. The Importance of Wound Biopsy in the Accurate Diagnosis of Acral Malignant Melanoma Presenting as a Foot Ulcer. (2013) Int. J. Low Extrem. Wounds.12 (4): 289-292.
• Kandolf Sekulović L, Cikota B, Jović M, Skiljević D, Stojadinovic O, Medenica L, Magić Z. The Role of Apoptosis and Cell Proliferation Regulating Genes in Mycosis Fungoides. J Dermatol Sci. 2009; 55(1):53-6.
• Kandolf Sekulovic L., Cikota B., Stojadinovic O., Basanovic J., Skiljevic D., Medenica Lj., Pavlovic M., Magic Z. TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. Acta Derm. Alp. Pan. Adriat.,16(4):149-55, 2007

Laser Treatments

• Pastar I, Liang L, Sawaya AP, Cao Wikramanayake T, Glinos GD, Drakulich S, Chen V, Stojadinovic O, Davis SC and Tomic-Canic M: Pre-clinical Models for Wound Healing Studies. Book titled “Skin Tissue Models” publisher Elsevier, Editors: Alexandra Marques, Rui L. Reis, Rogério P. Pirraco, Mariana T. Cerqueira (2017)

Other

• Pastar I, Sawaya AP, Jozic I, Stojadinovic O, Strbo N, Stone RC, Head CR, O’Neill K, Kornfeld E, Kirsner RS, Lev-Tov H, Tomic-Canic M: Intracellular Staphylococcus aureus Triggers Pyroptosis and Contributes to Inhibition of Healing Due to Perforin-2 Suppression, 2019, JCI in revision
• Sawaya AP, Jozic I, Stone RC, Pastar I, Egger AN, Stojadinovic O, Glinos GD, Kirsner RS, Tomic Canic M. Mevastatin promotes healing by targeting Caveolin-1 to restore EGFR signaling. JCI Insight. 2019 Oct 29. pii: 129320. doi: 10.1172/jci.insight.129320.
• Stone RC, Stojadinovic O, Sawaya AP, Glinos GD, Lindley LE, Pastar I, Badiavas E, Tomic-Canic M. A Bioengineered Living Cell Construct Activates Metallothionein/Zinc/MMP8 and Inhibits TGFβ to Stimulate Remodeling of Fibrotic Venous Leg Ulcers. Wound Repair Regen. 2019 Oct 31. doi:
• 1111/wrr.12778
• Rosen JD, Stojadinovic O, McBride JD, Rico R, Cho-Vega JH, Nichols AJ. Bowel-associated dermatosis-arthritis syndrome (BADAS) in a patient with cystic fibrosis. JAAD Case Rep. 2018 Dec 5;5(1):37-39.
• Sawaya AP, Pastar I, Stojadinovic O, Lazovic S, Davis SC, Gil J, Kirsner RS, Tomic-Canic M.Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5. J Biol Chem. 2018 Jan 26;293(4):1439-1449.
• Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ.Wound healing protects against chemotherapy induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling. Heliyon. 2017 May 30;3(5):e00309.
• Stojadinovic O 1, Stone RC, Rosa AM, Ramirez HA, Badiavas E, Blumenberg M, Tomic-Canic M. 1 These authors contributed equally to the work. A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers.Sci Transl Med. 2017 Jan 4;9(371).
• Jozic I, Vukelic S, Stojadinovic O, Liang L, Ramirez HA, Pastar I, Tomic Canic M.Stress Signals, Mediated by Membranous Glucocorticoid Receptor, Activate PLC/PKC/GSK-3β/β-catenin Pathway to Inhibit Wound Closure. J Invest Dermatol. 2016 Dec 22. pii: S0022 202X(16)32803-2. doi: 10.1016/j.jid.2016.11.036.
• Stojadinovic O, Lindley LE, Jozic I, Tomic-Canic M. Mineralocorticoid Receptor Antagonists-A New Sprinkle of Salt and Youth. J Invest Dermatol. 2016 Oct;136(10):1938-41
• Liang L, Stone RC, Stojadinovic O, Ramirez H, Pastar I, Maione AG, Smith A, Yanez V, Veves A, Kirsner RS, Garlick JA, Tomic-Canic M. Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions. Wound Repair Regen. 2016 Sep 8. doi: 10.1111/wrr.12470.
• Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and Biomarkers for Wound Healing. Plast Reconstr Surg. 2016 Sep;138 (3 Suppl):18S-28S.
• Pastar I, Stojadinovic O, Sawaya AP, Stone RC, Lindley LE, Ojeh N, Vukelic S, Samuels HH, Tomic Canic M.Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress and Migration. J Cell Physiol. 2016 Nov;231(11):2452-63
• Ojeh N, Pastar I, Tomic-Canic M, Stojadinovic O Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications. Int J Mol Sci. 2015 Oct 23; 16(10):25476-501.
• Ramirez HA, Liang L, Pastar I, Rosa AM, Stojadinovic O, Zwick TG, Kirsner RS, Maione AG, Garlick JA, Tomic-Canic M. Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin. PLoS One. 2015 Aug 28; 10(8):e0137133. doi: 10.1371/journal.pone.0137133.
• Jozic I, Stojadinovic O, Kirsner RS, Tomic-Canic M. Skin under the (Spot)-Light: Cross-Talk with the Central Hypothalamic-Pituitary-Adrenal (HPA) Axis. (2015) J Invest Dermatol.; 135 (6):1469-71.
• Maione AG, Brudno Y, Stojadinovic O, Park LK, Smith A, Tellechea A, Leal EC, Kearney CJ, Veves A, Tomic-Canic M, Mooney D, Garlick J.3D human tissue models that incorporate diabetic foot ulcer derived fibroblasts mimic in vivo features of chronic wounds. Tissue Eng Part C Methods. (2015) 21(5):499-508.
• Jozic I, Stojadinovic O, Kirsner RS, Tomic- Canic M. Stressing the steroids in skin: paradox or fine tuning? J Invest Dermatol. (2014) 134(12):2869-72.
• Ojeh N, Stojadinovic O, Pastar I, Sawaya A, Yin N, Tomic-Canic M. The effects of caffeine on wound healing. Int Wound J.( 2014) Jul 8. doi: 10.1111/iwj.12327
• Pastar I., Stojadinovic O, Yin N., Ramirez H., Nusbaum A., Sawaya A., Patel S.B., Khalid L., Isseroff R. R., Tomic-Canic M. Epithelialization in Wound Healing: A Comprehensive review. (2014) Advances in Wound Care 3(7):445-464.
• Strbo N., Yin N., Stojadinovic O Innate and Adaptive Immune Responses in Wound Epithelialization. (2014) Advances in Wound Care. 3(7):492-501
• Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M. Clinical Application of Growth Factors and Cytokines in Wound Healing. (2014) Wound Repair Regen. 22(5):569-78.
• Wikramanayake T.C., Stojadinovic O, Tomic-Canic M. Epidermal Differentiation in Barrier Maintenance and Wound Healing. (2014) Adv Wound Care.1; 3(3):272-280
• Stojadinovic O, Pastar I, Nusbaum, AG, Vukelic S, Krzyzanowska A and Tomic-Canic M: Deregulation of Epidermal Stem Cells Niche in Non-healing Venous Ulcers. (2014) Wound Repair and Regeneration, 22 (2): 149-153
• Stojadinovic O, Yin N, Lehmann J, Pastar I, Kirsner RS, Tomic-Canic M. Increased number of Langerhans cells in the epidermis of diabetic foot ulcers correlates with healing outcome. Immunol Res. 2013 Dec;57(1-3):222-8.
• Stojadinovic O, Tomic- Canic M. Human Ex vivo Wound Healing Model. (2013), Methods Mol Biol. 2013;1037: 255-64.
• Stojadinovic O, Minkiewicz J., Sawaya A., Bourne J.W., Torzilli P., de Rivero Vaccari j.P., Dietrich W.D., Keane R.W., Tomic-Canic M. Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load. (2013), PlosOne. 8(8):e69223.
• Stojadinovic O, Sawaya A, Pastar I and Tomic-Canic M: Glucocorticoid Receptor Localizes to Adherens Junctions at the Plasma Membrane of Keratinocytes, (2013), Plos One. 8(4):e63453.
• Stojadinovic O 1, Landon J.N. 1, Gordon K.A., Pastar I., Escandon J., Vivas A., Maderal A.D., Margolis D.J., Kirsner R.S., Tomic-Canic M. 1These authors contributed equally to the work. Quality Assessment of Tissue Specimens for Studies of Diabetic Foot Ulcers, Exp. Dermatology. (2013), 22 (3) 216–218
• G. Yu, O. Stojadinovic, M. Tomic-Canic, C. R. Flach, R. Mendelsohn: Infrared microscopic imaging of cutaneous wound healing: lipid conformation in the migrating epithelial tongue; Journal of Biomedical Optics 2012, 17(9), 96009-1
• Stojadinovic O, Gordon K., Labrun E., Tomic-Canic M. Stress-Induced Hormones Cortisol and Epinephrine Impair Wound Epithelialization Adv. in Wound Care. (2012);1;29-36
• Pastar I, Khan AA, Stojadinovic O, Lebrun EA, Medina MC, Brem H, Kirsner RS, Jimenez JJ, Leslie C, Tomic-Canic M. Induction of specific micro Ribonucleic acids (miRNAs) inhibits cutaneous wound healing J Biol Chem. (2012), 287(35):29324-35.
• Pechter PM, Gil J, Valdes J, Tomic-Canic M, Pastar I, Stojadinovic O, Kirsner RS, Davis SC. Keratin dressings speed epithelialization of deep partial-thickness wounds. Wound Repair Regen. (2012);20(2):236-42
• Pastar I, Ramirez H, Stojadinovic O, Brem H, Kirsner RS, Tomic-Canic M. Micro-RNAs: New Regulators of Wound Healing. Surg Technol Int. (2012) XXI:51-60
• Stojadinovic O1,Vukelic S1 , Pastar I, Rabach M, Krzyzanowska A, Lebrun E, Davis SC, Resnik S, Brem H, Tomic-Canic M. 1These authors contributed equally to the work. Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem.( 2011) 25; 286(12):10265-75
• Stojadinovic O, Ito M, Tomic-Canic M. Hair cycling and wound healing: to pluck or not to pluck? (2011) J. Invest. Dermatol. 131(2):292-4
• Stojadinovic O, Lebrun E, Pastar I, Kirsner R, Davis SC, Tomic- Canic M. Statins as Potential Therapeutic Agents for Wound Healing Disorders (2010) Expert Rev Dermatol. 5(6); 689-98
• Pastar I, Stojadinovic O, Krzyzanowska A, Barrientos S, Stuelten C, Zimmerman K, Blumenberg M., Brem H., Tomic-Canic M. Attenuation of TGFβ Signaling Pathway in Chronic Venous Ulcers. (2010) J. Mol. Med. 16(3-4):92-101
• Vukelic S, Stojadinovic O, Pastar I., Vouthounis C., Krzyzanowska A., Das S., Samuels S. S., Tomic Canic, M. Farnesyl Pyrophosphate Inhibits Epithelialization and Wound Healing Through the Glucocorticoid Receptor. (2010) J Biol Chem. 285(3):1980-8
• Stojadinovic O, Pastar I., Krzyzanowska A., Zimmerman K., Brem H.,Tomic-Canic, M. Change of fate of epidermal stem cells contributes to pathogenesis of chronic wounds. (2009) J Invest Dermatol 129:s5.
• Golinko MS, Joffe R, de Vinck D, Chandrasekaran E, Stojadinovic O, Barrientos S, Vukelic S, Tomic Canic M, Brem H. Surgical pathology to describe the clinical margin of debridement of chronic wounds using a wound electronic medical record. (2009) J Am Coll Surg. 209(2):254-260.e1
• Lee DD1, Stojadinovic O1, Krzyzanowska A, Vouthounis C, Blumenberg M, Tomic-Canic M. These authors contributed equally to the work. Retinoid- responsive transcriptional changes in epidermal keratinocytes. (2009) J Cell Physiol. 220(2):427-439, 2009
• Brem H, Kodra A, Golinko MS, Entero H, Stojadinovic O, Wang VM, Sheahan CM, Weinberg AD, Woo SL, Ehrlich HP, Tomic-Canic M. Mechanism of Sustained Release of Vascular Endothelial Growth Factor in Accelerating Experimental Diabetic Healing.(2009) J Invest Dermatol. 129(9):2275-87.
• Brem H., Golinko MS., Stojadinovic O, Kodra A., Diegelmann RF, Vukelic S., Entero H., Coppock DL.,Tomic-Canic M.: Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF, J. Transl. Med. 6(1):756:75, 2008
• Chan KL., Zhang G., Tomic-Canic M., Stojadinovic O, Flach CR., Mendelsohn R.: A Coordinated Approach to Cutaneous Wound Healing: Vibrational Microspectroscopic Imaging and Molecular Biology, J. Cell Mol. Med., 12 (5B): 2145- 1254, 2008
• Chandrasekaran EB., Golinko M., Vukelic S., Joffe R., Stojadinovic O, Tomic-Canic M., Brem H.: Pathology to define epidermal margin and depth of surgical debridement of diabetic foot ulcers, J. Am. Coll. Surg., 207 (3) : S52 ,2008
• Barrientos S., Stojadinovic, O., Golinko MS., Brem H., Tomic-Canic M.: Growth Factors and Cytokines in Wound Healing, Wound Repair and Regeneration, 16 (5): 585-590, 2008
• Tomic-Canic M., Ayello EA, Stojadinovic O, Golinko, MS, Brem, H: Using gene transcription patterns (bar coding scans) to guide wound debridement and healing. Adv Skin Wound Care. 21(10):493-494, 2008
• Tomic-Canic M., Ayello EA., Stojadinovic O, Golinko, MS., Brem, H.: Using gene transcription patterns (bar coding scans) to guide wound debridement and healing. Adv Skin Wound Care., 21(10):487-92; quiz 493-4, 2008
• Pastar I., Stojadinovic O, Tomic-Canic M.: Role of keratinocytes in healing of chronic wounds. Surg Technol Int., 17:105-12, 2008
• Charles CA., Tomic-Canic M., Vincek V., Nassiri M., Stojadinovic O, Eaglstein WH., Kirsner RS.: A gene signature of nonhealing venous ulcers: Potential diagnostic markers. J Am Acad Dermatol. 59 (5): 758-771, 2008
• Tomic-Canic M, Stojadinovic O, Lee B, Walsh R. , Blumenberg M.: Nexus Between Epidermolysis Bullosa and Transcriptional Regulation by Thyroid Hormone in Epidermal Keratinocytes, Clin. and Transl. Sci., 1 (1) 45-49, 2008
• Stojadinovic O, Pastar I., Vukelic S., Mahoney MG., Brennan D., Krzyzanowska A., Golinko MS., Brem H. and Tomic-Canic M: Deregulation of Keratinocyte Differentiation and Activation Pathways are a Hallmark of Pathogenesis of Chronic Wounds., J Cell Mol Med. 2008 Dec;12(6B):2675-90
• Harsha A.1, Stojadinovic O1, Brem H., Sehara-Fujisawa A., Wewer U., Loomis CA., Blobel CP, Tomic- Canic M: 1These authors contributed equally to the work. ADAM12: a Potential Target for the Treatment of Chronic Wounds. J. Mol. Med. 86(8):961-9, 2008
• Kandolf Sekulovic L., Cikota B., Stojadinovic O, Basanovic J., Skiljevic D., Medenica Lj., Pavlovic M., Magic Z. TCRgamma gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients. Acta Derm. Alp. Pan. Adriat.,16(4):149-55, 2007
• Brem H.1, Stojadinovic O1, Diegelmann RF., Entero H., Lee B., Pastar I., Golinko M., Rosenberg H., Tomic-Canic M. 1These authors contributed equally to the work. : Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement. , Mol. Med. 13 (1-2) 30-39, 2007
• Hwang J., Kalinin A., Hwang M., Anderson DE., Kim MJ., Stojadinovic O, Tomic-Canic M., Lee SH, Morasso MI: Role of scarf and its target proteins in epidermal calcium homeostasis. J Biol Chem., 282(25):18645-53, 2007
• Tomic-Canic M., Mamber W.S., Stojadinovic O, Lee B., Radoja N. and McMichael J.: Streptolysin O Enhances Keratinocyte Migration and Proliferation and Promotes Skin Organ Culture Wound Healing In Vitro. Wound Repair Regen. , 15(1):71-9, 2007
• Stojadinovic O, Lee B., Vouthounis C., Vukelic S., Pastar I., Blumenberg M., Brem H., Tomic-Canic M.: Novel Genomic Effects of Glucocorticoids in Epidermis: Inhibition of Apoptosis, IFNγ Pathway and Wound Healing along with Promotion of Terminal Differentiation. J Biol. Chem., 282(6):4021-34, 2007
• Stojadinovic O, Brem H. Vouthounis C., Lee B., Fallon J., Stallcup M., Merchant A., Galiano RD, Tomic- Canic M.: Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing, Am J Pathol. , 167(1): 59-69, 2005
• Jho S., Vouthounis C., Lee B., Stojadinovic O, Im MJ., Brem H., Merchant A., Chau K., Tomic-Canic M.:The book of opposites: the role of the nuclear receptor co-regulators in the suppression of epidermal genes by retinoic acid and thyroid hormone receptors, J Invest Dermatol., 124(5): 1034-43, 2005
• Lee B, Vouthounis C, Stojadinovic O, Brem H, Im M, Tomic-Canic M.:From an enhanceosome to a repressosome: molecular antagonism between glucocorticoids and EGF leads to inhibition of wound healing, J Mol Biol. ,345(5): 1083-97, 2005
• Radoja N., Stojadinovic O, Waseem A., Tomic- Canic M., Milisavljevic V., Teebor S., Blumenberg M.: Thyroid Hormones and Interferon-Gamma Specifically Increase K15 Gene Transcription, Mol Cell Biol. 24(8):3168- 79, 2004
• Pavlovic M.D., Zecevic R.D., Stamenkovic M.,Stojadinovic O, Zolotarevski L.: Trauma-induced perforating folliculitis, Eur J Dermatol.,13(6): 592, 2003
• Stojadinovic O: Dvadeset osam slucajeva juvenilnog pocetka Adamantijades- Behcetove bolesti u Nemackoj, Vojnosanitetski pregled, 57:610-611, 2000