Differential Diagnosis > Morphology > Color > White

White

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depigmented vs. hypopigmented

 

hmtoggle_plus1depigmented:
•vitiligo melanocytes absent
•toxic (chemical, trauma) to melanocytes
•piebaldism melanocytes absent
•albinism dysfunctional melnaocytes (tyrosinase positive vs. tyrosinase negative)

 

hmtoggle_plus1hypopigmented:
•post-inflammatory (problem with transfer of melanasomes to keratinocytes)
•albinism (tyrosinase positive vs. negative)
•pityriasis lichenoides chronica (“spotted leopard”)
•leprosy
•hypopigmented MF
•sarcoid

 

hmtoggle_plus1congenital hypopigmented:
•Nevoid Hypopigmentation
•Tuberous sclerosus (ash leaf macules = earliest sign)
•Nevus Anemicus (no actual pigment loss, but instead vascular constriction gives white appearance)
•IP (fourth stage)

 

hmtoggle_plus1hypopigmented and distinct (easy to dx):
•pityriasis alba
•idiopathic guttate hypomelanosis
•Tinea versicolor

 

hmtoggle_plus1atrophy:
•LS and A
•Degos’s disease
•atrophie blanche
•DLE

 

 

deposition: calcium e.g. heel stick calcfication, urate

 

other:

•fibrofolliculoma