Differential Diagnosis > Morphology > Reaction Patterns Expanded > Ulcers

Ulcers

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When you see erosions or ulcers, always consider vesicobullous in the ddx.

 

hmtoggle_plus1Ulcers (non-genital):
neoplastic
infectious
vascular
ulcerating panniculitis

 

hmtoggle_plus1Vegetative ulcers: (aka suppurative and verrucous)
pyoderma gangrenosum
halogenoderma
deep fungal (e.g. blastomycosis)

 

hmtoggle_plus1Necrotic Ulcers (eschar):
calciphylaxis
coumadin necrosis
anthrax
spider bite (brown recluse)
ecthyma gangrenosum

 

Genital Ulcer

 

Perineal Ulcer ddx:

metastatic Crohn's disease (non-caseating granulomas)
orificial TB (caseating granulomas)
amebiasis

 
Leg Ulcers:

 

Other Ulcers:

cancrum oris
BCC (rodent ulcer)
cryoglobulinemia (clinically = BPP with small ulcers)
factitial ulcers
hmtoggle_plus1neuropathic ulcer
diabetes mellitus, syringomyelia, lepromatous leprosy, hereditary neuropathy of Denny-Brown
~pressure necrosis

 

 

Vascular disease (“punched out ulcer right up to normal skin”)

e.g. DM, sickle cell, arteriosclerosis

 

Inflammatory inflamed skin at border, can probe under the red skin

e.g. pyoderma gangrenosum