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 (most common to less common) 
| • | hydroxyurea can cause severe painful leg ulcers (discontinuation heals) |  
   
see also Wound Healing 
  
  
Venous stasis ulcers: 
| • | location – medial ankle or lower calf |  
 | • | symptoms – painless or mild |  
 | • | characteristics – red base of granulation tissue; surrounding hyperpigmentation; depth: shallow; warm feet |  
   
Arterial ulcers (due to large vessels): 
| • | location – usually toes or foot;  lateral aspect of ankle |  
 | • | characteristics – black or gray base;  no granulation tissue; depth: deep;  cold feet |  
 | • | cause – arteriosclerosis obliterans, thromboangiitis obliterans |  
   
Neurotropic ulcers: 
| • | location – over metatarsal arch, heel, toes |  
 | • | characteristics – deep and surrounded by callus |  
 | • | cause – diabetes and other neuropathies |  
   
Hypertensive ulcers: 
| • | lateral and posterior calf;  severe pain |  
 | • | black eschar surrounded by purpura |  
  
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