| • | inhibits dihydrofolate reductase |
| • | selective toxicity because stronger for bacterial enzyme than for mammalian |
adverse effects:
| • | can produce the effects of folate deficiency (megaloblastic anemia, leukopenia, and granulocytopenia) |
| • | can be reversed with folinic acid (leucovorin) which does not enter bacteria |
Bactrim Doses:
| • | Skin staph infection: 1 DS tab PO BID |
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