Basic Science / Structures > Immune System > Cells > Lymphocytes > TH1 vs. TH2

TH1 vs. TH2

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A functional division of T- cells can be based on the cytokines they produce:

 

TH1 type

interferon gamma and IL-2
augment cell-mediated immune response by activating macrophages (e.g. delayed type hypersensitivity reactions)

 

TH2 type

IL-4, IL-5, and IL-10
augment humoral response, and inhibit some cell mediated response
IL-4 --> hypergammaglobulinemia;  switch in the antibody isotype from IgM to IgE
IL-5 -->  eosinophilia
IL-10 --> reduction in cell mediated immunity

 

 

diseases:

 

Psoriasis --> (CLA+) CD8 T-cells with Th 1 cytokines Th2 in the early phases; Th1 in the late and chronic phases

Allergic contact dermatitis --> (CLA+) CD8 T-cells with variable cytokine profile (both Th1 and Th2 cytokines)

Atopic dermatitis --> (CLA+) CD4 T-cells with Th2 cytokines

Mycosis Fungoides --> a tumor of (CLA+) CD4 T-cells

 

CTCL:

both resting and stimulated cells from the blood of patients with leukemic CTCL make cytokines of the Th2 type
the most commonly encountered malignant cutaneous T-cell is a Th2 CD45RO+ CLA+ T-cell

 

eosinophilic folliculitis:

preliminary evidence from both peripheral blood and skin of patients with eosinophilic folliculitis show the lymphocytes are making IL-4 and IL-5 but are not making gamma interferon or IL-2

 

Leishmaniasis:

Th1 LCL
Th2 disseminated infection  (therefore some treat with interferon gamma and antimony)

 

Leprosy:

tuberculoid leprosy - Th2
lepromatous leprosy - Th1