| • | directs T-cell homing to skin |
| • | it is an adhesion molecule that initiates the initial tethering of T-cells to the endothelium in cutaneous post-capillary venules |
| • | CLA positive Tcells represent 10-15% of all circulating T-cells in peripheral blood |
| • | (these T-cells may be positive for either CD4 or CD8, and once activated , they may be capable of producing either type 1 or type 2 T-cell cytokines) |
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