| • | can be taken without food |
| • | metabolized in the liver independent of P450 |
| • | mechanism: interferes with enzyme squalene epoxidase (= necessary for the first step in the conversion of squalene to ergosterol; the accumulation of squalene is fungicidal) |
| • | minor side effects = taste disturbance |
| • | effective topically, but not orally against t. versicolor |
| • | less active against Candida spp. in vitro; however clinical studies show otherwise |
Lamisil for tinea capitis: (x 6 weeks)
<20kg: 62.5mg/ day
(20 to 40kg): 125mg (= 1/2 tab)
| (>40kg): | 250mg (= 1 tab) qd |
|