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palpable purpura = vasculitis
| • | palpable because of inflammation |
| • | end stage of "vascular reaction pattern" (wheal = early stage) |
| • | septic = distal, sparse (small # of lesions), and asymmetric |
| • | hypersensitivity = symmetric bilateral lower extremities |
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Septic Vasculitis
| • | distal, sparse (small # of lesions), and asymmetric |
| • | if become generalized, think of superimposed DIC |
| • | embolization of organisms |
| • | pseudomonas (e.g. ecthyma gangrenosum) |
| • | subacute bacterial endocarditis |
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Hypersensitivity Vasculitis
| • | symmetric bilateral lower extremities; palpable purpura |
| • | etiologies: drug, group A beta-hemolytic strep (antecedent URI), collagen vascular disease |
| • | clinical ddx: benign pigmented purpura, scurvy, Kaposi's sarcoma |
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septic vs. hypersensitivity: