Basic Science / Structures > Immune System > Cells > Histiocytes > Mononuclear phagocyte system

Mononuclear phagocyte system

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•a widely distributed collection of both free and fixed macrophages derived from bone marrow precursor cells by way of monocytes
•connective tissue – histiocytes;  skin – histiocytes, Langerhans cells (?);  liver – Kupffer cells;  blood – monocyte;  spleen, LN, bone marrow – macrophage, bone – osteoclasts;  CNS – microglia;  lung, GI – macrophages