| • | active against dermatophytes only |
| • | MOA – deposits in skin; interferes with microtubule assembly (disrupts spindle formation, thus preventing mitosis etc..) |
| • | take with food, especially a fatty meal |
| • | long term dosing necessary – low affinity for keratin (6 mo’s for fingernails; 12 to 18 months for toenails) |
| • | also used to treat lichen planus (500mg BID) |
Griseofulvin ultramicrosize (Gris-PEG) 125mg; 250mg tablets (scored)
(FROM THE PACKAGE OF Gris-PEG)
peds: tinea capitis (can crush the tablet in food)
| • | 3.3mg/ pound (dosed QD) OR |
| • | 35 to 60 pounds: 125mg to 187.5mg PO QD |
| • | > 60 pounds: 187.5mg to 375mg PO QD |
adults:
| • | 375mg PO QD (or 250mg PO BID) tinea corporis, tinea cruris, tinea capitis |
| • | 375mg PO BID tinea pedis, tinea unguium |
treatment duration:
| • | Tinea capitis: 4 to 6 weeks |
| • | Tinea corporis: 2 to 4 weeks |
| • | Tinea pedis: 4 to 8 weeks (and use a topical) |
griseofulvin microsize:
| • | tinea capitis dose: (20-25 mg/kg/day) (≈10mg/lb/day) (QD or BID dosing) |
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