| • | a papular, nonlipidic, self-healing histiocytosis; affecting mainly adults |
| • | may continue for years, but subsides spontaneously |
| • | general health is always normal |
ddx:
| • | JXG and papular xanthoma – histology |
| • | multicentric reticulohistiocytosis – no arthritis or multinucleate giant cells in GEH |
| • | Benign Cephalic Histiocytosis – localized to face and only in children, but histologically closely related to BCH |
Think of the three "eruptive histiocyte" disease together:
Generalized Eruptive Histiocytosis
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ßà
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Xanthoma Disseminatum
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ßà
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Eruptive Xanthomas
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non-lipidized histiocytes
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|
xanthoma cells*
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xanthoma cells*
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|
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Touton giant cells
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Touton giant cells
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normal serum lipids
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normal serum lipids
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increased
triglycerides
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* xanthoma cells = lipidized histiocytes
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.
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