Eosinophils and neutrophils are closely related.
| • | They are both granulocytes, probably stimulated by similar cytokines |
| • | probably can treat neutrophilic and eosinophilic diseases with similar drugs?? (dapsone, colchicine) |
The clinical overlap includes:
| • | diseases with infiltrates of both (Sweet’s and Granuloma faciale) |
| • | the fact that neuts and eos can both form pustules (vs. lymphocytes or histiocytes) |
| • | both neutrophils and eos can give urticarial lesions (e.g. urticarial vasculitis vs. urticaria) |
| • | both neuts and eos can give blisters (e.g. DH vs. bullous pemphigoid) |
other thoughts:
| • | eos seem to be involved with type II hypersensitivity (at least in the bullous diseases e.g. BP) |
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