Differential Diagnosis > Distribution > Acral > Nails

Nails

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hmtoggle_plus1Subungual Hyperkeratosis ddx:
•=abnormal production of cornified cells by the nail bed
•fungal
•psoriasis
•pachyonychia congenita
•PRP
•idiopathic (occurs with old age)

 

hmtoggle_plus1onycholysis ddx:
•fungus
•drug
•trauma
•psoriasis

 

hmtoggle_plus1Blue lunula ddx:
•Wilson’s disease (rare)
•argyria
•drugs: (phenophthalein, busulfan, anti-malarials)

 

Cutaneous disease:

•psoriasis pitting; oil drop; subungual hyperkeratosis; onycholysis; splinter hemorrhages
•lichen planus
•onychomycosis

 

Nail Disorders:

•Twenty nail dystrophy (“of childhood”);
•Yellow Nail syndrome
•Laugier-Hunziker syndrome

 

hmtoggle_plus1Nail Findings in Systemic Disease:
•Systemic Sclerosis inverse pteryigium and nail beaking

Leukonychia:

•Terry’s nails
•Half and Half nails
•Muehrke’s paired white bands
•Mee’s lines

Nail Fold Capillary Microscopy:

•scleroderma
•dermatomyositis
•SLE

 

Genodermatoses:

•Ectodermal dysplasia hydrotic - anonychia and micronychia; anhidrotic - normal nails
•Nail-Patella syndrome in every case, the thumb nails are always involved (hypoplastic nails)
•Pachyonychia congenita pincer nails
•Tuberous Sclerosis (Koenen’s tumor i.e. periungual fibroma)
•Wilson’s disease:

 

Hyperpigmentation:

•Hutchinson’s sign
•AZT nails drug stimulates melanogenesis (similar mechanism to chemo), therefore it is NOT the drug that deposits

 

Glossary:

•pachyonychia – thickening of the entire nail plate;  may be found idiopathically in older persons
•trachyonychia – refers to rough nails with a sandpaper texture and appearance, as found in twenty nail dystrophy

 

 

 

Proximal portion of the matrix forms the superior aspect of the nail plate, and the distal matrix contributes to the inferior portion of the plate…

 

Pits:

•evidence of pinpoint damage to the matrix
•represent loci where tiny clusters of parakeratotic cells have been shed from the surface of the nail plate

 

White spots (leukonychia):

•result from damage to the distal matrix (vs. pits)
•represent parakeratotic cells in the deeper portion of the nail plate