| • | a rare disease caused by zygomycete fungi* |
| • | = ubiquitous molds common in the soil |
| • | etiologic agents – rhizopus (#1), mucor, absidia |
| • | rhinocerebral zygomycosis |
| • | classic = patient in DKA diabetic ketoacidosis |
| • | acute rapidly progressive infection |
| • | begins in paranasal sinus; nasal discharge, facial swelling, ulceration |
| • | treatment – control diabetes, surgical debridement, amphotericin B |
| • | now called "zygomycoses" |
| • | invades blood vessels causing tissue necrosis |
| • | classic presentation = rhinocerebral mucor in a patient with diabetic ketoacidosis (infection of sinuses manifest with acute edema, erythema and fever) |
| • | tender indurated large plaque with dusky center, an area of necrotizing cellulitis |
| • | ulceration, ecthyma-gangrenosum-like lesions, and necrotic abscesses |
| • | diagnosis – culture and stain biopsy tissue |
| • | treatment – excision of affected tissue; amphotericin B |
*
class - zygomycetes
order – mucorales
family – mucoracae
genera:
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