Pathogenesis > Infectious Disease > Protozoa > Trypanosomiasis

Trypanosomiasis

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two forms:

•Africa – sleeping sickness – T. rhodesiense and T. gambiense – tse tse fly – Winterbottom’s sign
•S. America – Chagas’ disease – Trypanosoma cruzi – cone nosed bug (AKA kissing bug) – Romaña sign
•mnemonic:  think of Tom Cruz the American actor who kisses everybody (or 3 C’s:  Chagas’, cruzi, cone nosed bug)

 

Winterbottom sign = swelling of the posterior cervical lymph nodes (characteristic of early stages of African trypanosomiasis)

Romaña sign = unilateral eyelid edema (suggests acute Chagas disease)