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picornavirus = “little RNA virus” (picoRNAvirus)
| • | this family of viruses have similar structure and replication |
| • | there are two genera: enterovirus and rhinovirus |
enterovirus:
| • | infect intestinal epithelial and lymphoid (tonsils, Peyer’s patches) cells |
| • | spread by fecal-oral route |
| • | hepatitis A virus, poliovirus, Coxsackie A, B, and echovirus |
Hand, Foot and Mouth disease:
| • | pathogen = coxsackie A16 |
| • | mild symptoms of low grade fever, sore-throat |
| • | enanthem: 90%; apthae-like erosions, small and asymptomatic |
| • | cutaneous lesions: 2/3 of patients… |
| • | within 24 hours of enanthem |
| • | red macules that rapidly become pale, white, oval to cigar-shaped vesicles with a red areola |
| • | hands and feet, especially palms and soles |
| • | heal in 7 days without crusting or scarring |
| • | culture virus from stool; acute and convalescent serum titers |
| • | histology: reticular degeneration (multilocular blisters vs. herpes virus) |
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