| • | AKA palmoplantar hyperkeratosis and periodontosis |
| • | autosomal recessive |
| • | (+) transgradiens (= extension to dorsal surface, Achilles’ tendon) |
| • | periodontitis with severe gingivitis (by early teens most patients have lost all their permanent teeth) |
| • | hyperkeratotic plaques on elbows and knees |
| • | pyogenic infections |
| • | defect = cathepsin |
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