Basic Science / Structures > Immune System > Cells > Neutrophils

Neutrophils

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•major task is ingestion and elimination of noxious material
•2 types of granules:
1.azurophilic granules
•25% of granules in the neutrophil
•larger
•contain hydrolytic enzymes and peroxidase
2.specific granules
•75% of granules
•smaller
•major constituent is alkaline phosphatase

 

 

many neutrophilic disease are caused by immune complexes

 

hmtoggle_plus1many neutrophilic disease have IgA: (the secretory immunoglobulin)
•HSP (IgA DIF)
•DH (IgA DIF)
•linear IgA bullous dermatitis/ chronic bullous dermatitis of childhood  (IgA DIF)
•Subcorneal Pustular Dermatosis (IgA subset)
•EED (IgA paraproteinemia)
•Berger’s disease

 

hmtoggle_plus1 Dapsone treats neutrophilic disease:
•DH (invariably responds)
•SPD
•EED (invariably responds)
•G. faciale (?)
•bullous SLE
•Sweet's syndrome
•pyoderma gangrenosum
•+/- LCV