By Disease Name > Hypereosinophilic syndrome
Hypereosinophilic syndrome
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•
a diagnosis of exclusion, defined by:
•
> 1500 eosinophils/ mm3
•
for > 6 months
•
with no underlying disease to explain the eosinophilia
•
90% of reported cases are
men
age 20 to 50
•
skin: (50% of patients):
angioedema
and
urticarial
lesions commonly
•
cardiac disease
is the most frequent systemic complication (presenting as failure or arrhythmias) and the most common cause of morbidity and mortality
•
etiology
–
dysregulated overproduction of eosinophils in patients who lack a malignant disorder (increased levels of
IL5
)