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Meds:
| • | vancomycin – “red man syndrome”; releases histamine |
| • | dry flushing: vasodilatation (e.g. adriamycin, cisplatin) |
| • | wet flushing: eccrine sweating, more autonomic (e.g. anti-hormone drugs – flutamide, tamoxifen) |
Three syndromes:
| • | carcinoid syndrome, pheochromocytoma, mastocytosis |
Facial flushing:
| • | alcohol – may uncover subclinical carcinoid or mastocytosis |
| • | disulfiram-like reactions to alcohol – after certain drugs (e.g. griseofulvin, metronidazole, anti-diabetic drugs) |
| • | nicotinic acid – may be prostaglandin mediated (blocked by indomethacin and aspirin) |
| • | (naloxone blocks alcohol and menopausal flush therefore opioid's may play a role) |
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