Pathogenesis > Nutrition > Calcium

Calcium

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Calcinosis cutis

dystrophic calcification secondary to tissue damage - dermatomyositis (especially juvenile), CREST, heel stick calcification (of newborn) secondary to nursery sticks, white, resolves spontaneously before child walks
metastatic calcification increased serum level of calcium or phosphate - calciphylaxis
idiopathic calcification unassociated with tissue damage or demonstrable metabolic disorder - idiopathic scrotal calcinosis, subepidermal calcified nodule (of newborn)

 

 

hmtoggle_plus1Hypercalcemia
symptoms = nephrolithiasis, constipation, vomiting, depression  (mnemonic = stones, abdominal groans, and psychiatric overtones)
sarcoid hypercalcemia 11%, hypercalcuria 40%
check for hypercalcemia in subcutaneous fat necrosis of the newborn

 

hmtoggle_plus1Hypocalcemia
found in pustular psoriasis mnemonic - there is an "o" in psoriasis, but no "er" (reminds one it is "hypo-" NOT "hyper-" calcemia), STTS (basis unclear)

 

 

 

Disease:

Calcium:

 

 

Sturge-Weber syndrome

tram-track calcification of ipsilateral cortex

 

 

basal cell nevus syndrome

calcification of falx cerebri

 

 

Darier’s disease

mutation = SERCA2 gene  (encodes a Ca2+-

transporting ATPase)

 

 

sarcoid

hypercalcemia 11%, hypercalcuria 40%

 

 

subcutaneous fat necrosis of newborn

check for hypercalemia

 

 

pustular psoriasis

hypocalcemia

 

 

Lesions with calcium as part of histology PXE, pilomatricoma, subcutaneous fat necrosis of the newborn