Calcinosis cutis
• | idiopathic calcification unassociated with tissue damage or demonstrable metabolic disorder - idiopathic scrotal calcinosis, subepidermal calcified nodule (of newborn) |
• | symptoms = nephrolithiasis, constipation, vomiting, depression (mnemonic = stones, abdominal groans, and psychiatric overtones) |
• | sarcoid – hypercalcemia 11%, hypercalcuria 40% |
• | check for hypercalcemia in subcutaneous fat necrosis of the newborn |
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• | found in – pustular psoriasis mnemonic - there is an "o" in psoriasis, but no "er" (reminds one it is "hypo-" NOT "hyper-" calcemia), STTS (basis unclear) |
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Disease:
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Calcium:
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Sturge-Weber syndrome
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tram-track calcification of ipsilateral cortex
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basal cell nevus syndrome
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calcification of falx cerebri
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Darier’s disease
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mutation = SERCA2 gene (encodes a Ca2+-
transporting ATPase)
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sarcoid
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hypercalcemia 11%, hypercalcuria 40%
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subcutaneous fat necrosis of newborn
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check for hypercalemia
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pustular psoriasis
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hypocalcemia
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Lesions with calcium as part of histology PXE, pilomatricoma, subcutaneous fat necrosis of the newborn
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