|
| type II collagen | relapsing polychondritis |
| type VII collagen | EBA; bullous SLE |
| desmoglein 3 (130kd) | pemphigus vulgaris; pemphigus vegetans |
| desmoglein 1 (160kd) | pemphigus foliaceus |
| bullous pemphigoid antigen I (230kd) | bullous pemphigoid |
| bullous pemphigoid antigen II (180kd) = a transembrane protein (therefore it spans many diseases) | bullous pemphigoid; cicatricial pemphigoid; pemphigoid gestationis mnemonic: You’re 18 years old when you get pregnant and get herpes gestationis which has a 180kd antigen, which is a transmembrane protein (and therefore spans many diseases) |
| anti mitochondrial antibody | primary biliary cirrhosis (90%) |
| anti-smooth muscle antibodies | sclerosing cholangitis |
| topoisomerase I | Scl 70 (PSS) |
| proteinase 3 | c-ANCA (Wegener’s Granulomatosis) |
| ribonucleoproteins (sRNP) | ENA’s (Sm, Ro/La, U1RNP) |
| histidyl t-RNA synthetase | Jo-1 (aggressive Myositis with interstitial lung dz) |
Serologic profiles in CTD’s:
|
|
nDNA
|
Sm
|
U1RNP
|
Ro
|
La
|
Centromere
|
Scl-70
|
Histone
|
ANA
|
Disease
|
+
|
+
|
|
|
|
|
|
|
≈100%
|
SLE
|
-
|
-
|
+
|
|
|
|
|
|
≈100%
|
MCTD
|
-
|
-
|
-
|
+
|
+
|
|
|
|
|
Sjogren's, SCLE
|
-
|
-
|
-
|
-
|
-
|
-/+
|
+/-
|
|
95%
|
SSc/ CREST
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
+
|
|
Drug-SLE
|
|